@article {548376,
	title = {Evaluation of a bone{\textquoteright}s in vivo 24-hour loading history for physical exercise compared with background loading},
	journal = {J Orthop ResJ Orthop ResJ Orthop Res},
	volume = {16},
	number = {1},
	year = {1998},
	note = {Konieczynski, D DTruty, M JBiewener, A AengAR39828-01A1/AR/NIAMS NIH HHS/Comparative StudyResearch Support, U.S. Gov{\textquoteright}t, P.H.S.1998/05/09J Orthop Res. 1998 Jan;16(1):29-37.},
	month = {Jan},
	pages = {29-37},
	abstract = {The present study sought to answer two research questions. First, how distinctive, as a potential osteogenic stimulus, are short-duration bouts of treadmill exercise relative to sedentary background activity? Second, how well does daily effective strain stimulus relate the loading history for one such exercise program, in comparison with other experimental loading programs, to bone formation? In vivo cortical strains were measured in the tibiotarsus of White Leghorn chickens at a late stage of skeletal growth (14-34 weeks old) under the conditions of a previous investigation of bone formation in response to an exercise program (15 min/day, treadmill gait at 60\% maximum speed while carrying 20\% body mass) that included sedentary background activity. These strain data were compiled into 24-hour loading histories of peak cyclic strain, demonstrating that strains were statistically different for exercise and background activities (p < 0.0001), with both the magnitude and number of cyclic strain events being greater during exercise (generally greater than 500 microstrain, 2,500 cycles/day) than during background activity (generally less than 500 microstrain, mean: 775 cycles/day). Strains during exercise accounted for more than 97\% of the daily effective strain stimulus for bone adaptation, despite the fact that exercise comprised only 1\% of the daily period (15 min/day). The levels of the daily effective strain stimulus were similar to those calculated for strains engendered by artificial loading of functionally isolated avian ulnae, which either maintained bone mass or resulted in a 15\% increase of cortical cross-sectional area in both sets of studies. These results indicate that short-duration bouts of treadmill exercise and sedentary background activity can represent distinct osteogenic stimuli for adaptive bone modeling. They also provide experimental support for the use of a daily effective strain stimulus to quantify skeletal loading histories for differing programs of physical exercise, although the relative importance of other mechanical and nonmechanical factors requires further investigation.},
	keywords = {*Physical Conditioning, Animal, Animals, Bone and Bones/*physiology, Bone Development, Chickens, Female, Male, Time Factors},
	isbn = {0736-0266 (Print)0736-0266 (Linking)},
	author = {Konieczynski, D. D. and Truty, M. J. and Biewener, A. A.}
}
